Hydrogen peroxide vapor sensing measures were suggested

If you missed our recent webinar "in facilities and airtight system effectively H2O2 biological purification", you canwatchRecord the version of the.

During the webinar, we received a lot of have no time to answer the question.After our professional staff will answer your question, here, we share a universal problem for the following three categories:

• Vaporization hydrogen peroxide sensor
• Equipment, materials and structures
• Biological indicator

Vaporization hydrogen peroxide sensor

Q: when we are in the cycle development using typical RH sensors, they measure the relative humidity or relative saturation?In other words, the vaporization H₂O₂Will affect the typical RH of RH sensor readings?

A: water and hydrogen peroxide have very similar molecular structure, and both affect its own air humidity.No catalytic layer, therefore, typical of the RH sensors will have greater than mixture of the actual level of saturation humidity value.So, vaporization of H₂O₂Do affect the typical humidity sensor, and due to repeated exposure in acceleration sensor drift.Relative humidity sensor with catalytic layer can be measured only by the air humidity caused by water vapor.After exposure to H₂O₂During the RH % value is lower than the relative saturation RS %.throughThis online seminarTo know more information about the relative degree of saturation.

In addition, visa also provides with sensors (including catalytic layer) traditional RH/temperature instrument.The catalytic layer, plus our heated probe technique and chemical removal function, can be in the presence of vaporizing H₂O₂Provide the real RH measurement.Information about these other instruments:

Temperature and humidity sensor HMP3

Temperature and humidity instrument HMT330 series

Hydrogen peroxide HPP270

Equipment, materials and structures

Q: whether the suggestion in the atomization system use H vaporization₂O₂?

Answer: in both cases, HPP270 series probe can be used for measuring evaporation of H₂O₂.When choosing a system used for the biological purification, need to consider multiple variables.Visa does not provide a carburetor or atomization system.We provide sensing device, used for intelligent monitoring and control of key process.Please contact system vendor, see if the equipment can meet your application requirements.

Q: H₂O₂What equipment and purification usually use MOC (maintenance) condition, including the room structure, hvac system, including pipe seal)?I have seen it is necessary to use dynamic seal to block the fermentation chamber reflow pipe and supply, not only because the air processor is connected to the fermentation chamber, and there will be vaporized hydrogen peroxide flow back to have in other areas of the user's risk.

A: we recommend that you see in the network during the seminar we provide resources.In other words, we need to be able to withstand H₂O₂The erosive effects of condensation.

Q: can you for vaporizing H₂O₂Absorbed by the material in the room or isolator, and then after the ventilation loss over time report for review?Whether this leaching effect may lead to accumulation in the ventilated area or in the H₂O₂The deactivation fumigation facilities in the production of products?

A: thank you put forward this problem, although the visa cannot comment H vaporization₂O₂Desorption results, but we do know that certain material at different rates and concentrations of H to absorb and release vapors₂O₂.In view of the technological process of the regional and items carefully select material, combined with adequate ventilation duration, can help reduce the potential impact.In view of the problem areas in the right circulation development can include ventilation after stage, this stage may involve other low level monitoring.

Q: twice each year in a purification and extraction by metal pipeline system H₂O₂In the laboratory, as time goes by, the possibility of corrosion to occur in the pipe system have how old?

A: to provide a reliable answer, too many variables to consider.Security answer is: if there is corrosion of pipeline system makes vaporization of exposure to extract in different regions of the H₂O₂Under the unsafe levels of risk, should be check regularly.

Factors affecting corrosion possibility may be process used in the evaporation concentration of H2O2, in biological purification cycle condensate, or risk of condensation in the pipe system in the laboratory.If the temperature of the exhaust pipe is lower than the drying air, then the risk of condensation and corrosion will be higher.

Q: what kind of purification methods: better through the air handling unit, or injected directly into the interior?

A: if only one room for biological purification, then use the steam generator in the room may be more easily.Most of our clients are from integration to the room or the positions of the isolator using thermal evaporation.The steam generator is easy to control, and temperature difference is more easier to manage.

Biological indicator

Q: how do we study biological purification challenges to choose the location of the biological indicator?

Answer: although the visa does not sell biological indicator, but we have seen many customers will be biological purification biological indicator in they think are difficult to place.Biomarkers of suppliers can provide the product specifications and guidelines.But some sterilization service will provide the experience in the blog and other publications.This is from a service provider Ardien Consulting blogs:Naughty biological indicator.

Q: do you suggest placing biological indicator in triplicate to prevent biological indicator "naughty"?Do you recommend (in one place) duplicate or in triplicate run biological indicator?

A: thank you for this question, but visa cannot not directly involved in the product and method for us to provide guidance.I suggest you see with the webinar we provide resources.In spite of this, but we know, the use of repetition of biomarkers to improve the level of guarantee is very common, and in triplicate biological indicator can be used to more challenging field.

The following are some of the resources industry groups to provide, some of which are available for purchase:

• "Bacillus genus ordinary resistance of spores of gasification hydrogen peroxide"M. Kokubo, Inoue and t. j. Akers, PDA medical technology magazine, 52, 5

• "H.₂O₂The development of the purification cycle and quantitative"Volker Sigworth, Claude Moirandat, PDA medical technology magazine, 54, no. 4

• "About for aseptic processing and sterility test isolator's advice"Drug inspection cooperation plan in 2002

• ISO 11138-1 health care products sterilization - biological indicator - part 1: general requirements